Equipe 5 : Epidémiologie des Maladies Allergiques et Respiratoires (EPAR)

Responsable(s) :
  • Isabella ANNESI-MAESANO isabella.annesi-maesano at inserm.fr

Presentation de l'équipe

Allergic and respiratory diseases affect a relevant segment of the population resulting in significant social and economic burden and their prevalence is increasing worldwide. Taking the most known diseases, according to the World Health Organization (WHO), there are now at least 300 million people suffering from asthma and over 200 million people suffering from COPD that includes chronic bronchitis and emphysema. In terms of mortality, each year in the world there are almost 250,000 asthma-related deaths and COPD ranks at the 5th leading cause of death. In addition, a WHO/World Bank projection to 2020 brings COPD to the 3rd leading cause of death with 4.7 million deaths. Although other allergic and respiratory diseases like rhinitis, drug allergy, pulmonary interstitial diseases … are also very common at the population level, their burden has still to be estimated.

EPAR’s main research aims consist in 1) the identification of allergic and respiratory phenotypes/endotypes and their distribution and 2) the determination of the role of environmental risk factors in the aggravation and the development of these phenotypes in view to explain the augmentation of the prevalence of these conditions in the past decades.

The central hypothesis of EPAR is that, in order to explain the increase of allergic and respiratory diseases observed in the past decades, it is essential to take into account that these are heterogeneous conditions displaying different phenotypes and underlying endotypes and that the role of risk factors varies according to the type of phenotype/endotypes. In this field, main recent results concern the identification of phenotypes of asthma in early childhood when diseases develop and the comprehension of the impact of indoor and outdoor air pollution on asthma and COPD in susceptible populations, young children and elderly respectively. Ongoing work on the comprehension of the increase of allergic and respiratory diseases covers additional allergic and respiratory diseases (registries are starting for severe sarcoidosis and drug allergy) and takes into account other etiological and modifier factors. From the etiological point of view, the expology and exposome approaches are taken into account, namely in the frame of the HEALS project that EPAR is leading (www.heals-eu.eu). The exposome is the totality of external exposures and internal consequences as assessed through “omics” that characterize the lifespan of the individuals. Such a new paradigm has been introduced to better explain the development and the increase of major chronic diseases including allergic and respiratory diseases that has not been elucidated using the classical approach based on the relationship of one risk factor to the disease after adjusting for confounders, all the variables assessed in short periods. One specificity of HEALS resides in the fact that HEALS dispose of general population studies having recruited both singletons and twins, monozygotic twins being particularly adapted to effect of the environment in particular through the consideration of epigenetics and of the action some environmental factors have on epigenetic mechanisms.

Among major modifiers of the relationships between and health outcomes, the influence of medical treatment (including immunotherapy) on the evolution of these diseases, is taken into account.

The prevention component is consolidated thanks to the Department of General Practice of UPMC Paris Sorbonne Universités, which works on the respiratory effects of indoor air pollution at the primary care level and on the relationships between air pollution and overweight and obesity in asthmatic and non-asthmatic populations. The projects progression will be based on the development of novel methods for assessing human exposure (expology) and statistics applied to the case of allergy and respiratory disease (DAG, predictive models…).

EPAR is presently involved in the following research projects: EU FP7-ENV HEALS (as PI), Life + MED’HISS (WP leader), Life + AIS (WP Leader), EDEN birth cohort, ELFE birth cohort, ASTHM’CHILD, PAALM, BALISTIC, Register of Severe Sarcoïdosis, OQAI.

Membres de l'équipe

Nom Contact Statut / Fonction
Flore AMAT flore.amat at iplesp.upmc.fr Doctorant-e
Michel AMOUYAL Professeur des Universités
Fouad AMRANI fouad.amrani at iplesp.upmc.fr Ingénieur d'Etude / Epidemiologie-statistique
Isabella ANNESI-MAESANO isabella.annesi-maesano at inserm.fr Directeur de Recherche
Christelle Audi christellea92 at gmail.com Etudiant-e / Stagiaire de Master
Nour BAIZ nour.baiz at upmc.fr Post-Doctorant-e
Fatima BENAISSA benaissa_fatima at ymail.com Etudiant-e / Doctorant-e
Salima BENHMEDI salima.benhmedi at u707.jussieu.fr Praticien Hospitalier
Jean-François BERTHOLON jean-francois.bertholon at upmc.fr MCU-PH
Philippe Jean Jacques BOUSQUET philippe.bousquet at lsce.ipsl.fr PHU
Pascal DEMOLY pascal.demoly at inserm.fr PU-PH
Nathalie GUILLEMOT-LAMBERT nathalie.guillemot-lambert at iplesp.upmc.fr Praticien Hospitalier
Delphine HABOURIA MICHON Ingénieur hospitalier
Wideline JACQUES wideline.jacques at upmc.fr
Jocelyne JUST jocelyne.just at trs.aphp.fr PU-PH
Jean LAFORTUNE jean.lafortune at upmc.fr PU Associé
Sandrine LAUNOIS sandrine.launois at aphp.fr MCU-PH
Pierre LEVY pierre.levy at tnn.aphp.fr Praticien Hospitalier
Sese Lucile lucile.sese at gmail.com Stagiaire de Master
Vinh-Phuc LUU vinhphuc22000 at gmail.com Médecin Epidémiologiste / Interne de Santé Publique
Myriam M’RAD myriam.mrad at usj.edu.lb Doctorant-e
Cara MAESANO cara.maesano at iplesp.upmc.fr Ingénieur de Recherche
Anne Marie MAGNIER anne-marie.magnier at upmc.fr Directeur de Recherche
Malika MAHLOUL malika.mahloul at upmc.fr Ingénieur hospitalier
Luc MARTINEZ luc.martinez at upmc.fr PU Associé
Safia Mohamed Ali mohamed-ali.safia at live.fr Stagiaire de Master
Amir MOUSTAFA amir.moustafa at upmc.fr Ingénieur d'Etude / Chef de projet
Laure Parnet 8providence at gmail.com Interne de Médecine Générale
Shafiq REHMAN Doctorant-e
Philippe SAINT-PIERRE philippe.saint_pierre at upmc.fr MCU
Shreosi Sanyal shreosi.sanyal at iplesp.upmc.fr Post-Doctorant-e
Katia Solin-Skrodzki katia.solin at gmx.com Etudiant-e / Stagiaire de Master
Munawar Hussain SOOMRO Etudiant-e / Doctorant-e
Dominique TIRMARCHE MCU Associé
Nicolas VELAIDOMESTRY velaidomestrynicolas at hotmail.fr Etudiant-e / Stagiaire de Master
Jean-François VIBERT jean-francois.vibert at upmc.fr Professeur Emérite
Hassani YOUSSOUF youssouf at u707.jussieu.fr Doctorant-e

Sites internet de l'équipe

Nom Adresse
XNBC : a software package to simulate biological neural networks for research and education http://ticemed_sa.upmc.fr/xnbc/
Site de l'équipe Epar http://www.epar.fr/