Equipe 6 : Epidémiologie hospitalière, qualité et organisation des soins

Responsable(s) :
  • Gilles HEJBLUM @ : gilles.hejblum at upmc.fr

Presentation de l'équipe

The research developed in the team is especially concerned with the processes involved in the organization and quality of care at the hospital. Decision making is also a keyword frequently associated with our research. Synergetic objectives of the team include documenting the current situation, exploring hypotheses for improvement, and guiding research or public decision in several issues.

Research involves various methods, often combined:
- Epidemiological / statistical methods (e.g. randomized trials),
- Modelling (e.g. cost-effectiveness modelling),
- Information systems (e.g., use of databases already available, specific software developments).

A part of our research concerns global organization while other parts of our research particularly focus on a process or an intervention at a specific timing of the hospital stay: admission, hospital stay strictly speaking, or discharge.

A substantial part of the past, current, and future research projects concerns intensive care, including for example, the volume-outcome relationship, the prescription of chest x-rays in ventilated patients, and admission of elderly patients in the intensive care unit. Recent projects are more concerned with adverse events, and some of them are especially related to adverse drug events.

In order to illustrate our scientific production on past and current projects, some corresponding documents (and their links to full-text) are listed below according to above-mentioned characteristics of our research.




 


Global organization



Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription (HYPAGE)



Nguyen YL, Wallace DJ, Yordanov Y, Trinquart L, Blomkvist J, Angus DC, Kahn JM, Ravaud P, Guidet B. The Volume-Outcome Relationship in Critical Care: A Systematic Review and Meta-analysis.

Chest

2015;148:79-92.



Nguyen YL, Perrodeau E, Guidet B, Trinquart L, Richard JC, Mercat A, Jolliet P, Ravaud P, Brochard L. Mechanical ventilation and clinical practice heterogeneity in intensive care units: a multicenter case-vignette study.

Ann Intensive Care

2014;4:2.



Nguyen YL, Milbrandt EB, Weissfeld LA, Kahn JM, Chiche JD, Aegerter P, Clermont G, Kellum JA, Guidet B, Angus DC. Intensive care unit renal support therapy volume is not associated with patient outcome.

Crit Care Med

2011;39:2470-7.



Ioos V, Galbois A, Chalumeau-Lemoine L, Guidet B, Maury E, Hejblum G. An integrated approach for prescribing fewer chest x-rays in the ICU.

Ann Intensive Care

2011;1:4.



Valentin A, Capuzzo M, Guidet B, Moreno R, Metnitz B, Bauer P, Metnitz P. Errors in administration of parenteral drugs in intensive care units: multinational prospective study.

BMJ

2009;338:b814.


 


Admission



Hejblum G, Atsou K, Dautzenberg B, Chouaid C. Cost-benefit analysis of a simulated institution-based preoperative smoking cessation intervention in patients undergoing total hip and knee arthroplasties in France.

Chest

2009;135:477-83.



Boumendil A, Latouche A, Guidet B. On the benefit of intensive care for very old patients.

Arch Intern Med

2011;171:1116-7.


 


Hospital stay strictly speaking



Bigé N, Hejblum G, Baudel J, Carron A, Chevalier S, Pichereau C, Maury E, Guidet B. Homeless patients in the Intensive Care Unit: an observational propensity-matched cohort study.

Crit Care Med

2015;43:1246-54.



Galbois A, Aegerter P, Martel-Samb P, Housset C, Thabut D, Offenstadt G, Ait-Oufella H, Maury E, Guidet B. Improved prognosis of septic shock in patients with cirrhosis: a multicenter study.

Crit Care Med

2014;42:1666-75.



Guidet B, Hodgson E, Feldman C, Paruk F, Lipman J, Koh Y, Vincent JL, Azoulay E, Sprung CL. The Durban World Congress Ethics Round Table Conference Report: II. Withholding or withdrawing of treatment in elderly patients admitted to the intensive care unit.

J Crit Care

2014;29:896-901.



Hejblum G, Ioos V, Vibert JF, Boelle PY, Chalumeau-Lemoine L, Chouaid C, Valleron AJ, Guidet B. A web-based Delphi study on the indications of chest radiographs for patients in ICUs.

Chest

2008;133:1107-12.



Galbois A, Ait-Oufella H, Baudel JL, Kofman T, Bottero J, Viennot S, Rabate C, Jabbouri S, Bouzeman A, Guidet B, Offenstadt G, Maury E. Pleural ultrasound compared with chest radiographic detection of pneumothorax resolution after drainage.

Chest

2010;138:648-55.



Hejblum G, Chalumeau-Lemoine L, Ioos V, Boelle PY, Salomon L, Simon T, Vibert JF, Guidet B. Comparison of routine and on-demand prescription of chest radiographs in mechanically ventilated adults: a multicentre, cluster-randomised, two-period crossover study.

Lancet

2009;374:1687-93.


 


Discharge



Couturier B, Carrat F, Hejblum G. A Systematic Review on the Effect of the Organization of Hospital Discharge on Patient Health Outcomes.

BMJ Open

2016;6(12):e012287.



Couturier B, Carrat F, Hejblum G; SENTIPAT Study Group. Comparing patients’ opinions on the hospital discharge process collected with a self-reported questionnaire completed via the Internet or through a telephone survey: an ancillary study of the SENTIPAT randomized controlled trial.

J Med Internet Res

2015;17:e158.



Sentinel Patients: Value of an Information System Collecting Patient’s Own Report on His Healthcare Management


 


Modelling



Atsou K, Crequit P, Chouaid C, Hejblum G. Simulation-based estimates of the effectiveness and cost-effectiveness of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease in France.

PLoS One

2016;11(6):e0156514.



Fardet L, Galicier L, Lambotte O, Marzac C, Aumont C, Chahwan D, Coppo P, Hejblum G. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome.

Arthritis Rheumatol

2014;66:2613-20.



Atsou K, Chouaid C, Hejblum G. Simulation-based estimates of effectiveness and cost-effectiveness of smoking cessation in patients with chronic obstructive pulmonary disease.

PLoS One

2011;6:e24870.



Hejblum G, Atsou K, Dautzenberg B, Chouaid C. Cost-benefit analysis of a simulated institution-based preoperative smoking cessation intervention in patients undergoing total hip and knee arthroplasties in France.

Chest

2009;135:477-83.



Wargon M, Guidet B, Hoang TD, Hejblum G. A systematic review of models for forecasting the number of emergency department visits.

Emerg Med J

2009;26:395-9


 


Information systems



Hejblum G, Lambotte O, Galicier L, Coppo P, Marzac C, Aumont C, Fardet L. A web-based delphi study for eliciting helpful criteria in the positive diagnosis of hemophagocytic syndrome in adult patients.

PLoS One

2014;9:e94024.



Jolivot PA, Hindlet P, Pichereau C, Fernandez C, Maury E, Guidet B, Hejblum G. A systematic review of adult admissions to ICUs related to adverse drug events.

Crit Care

2014;18:643.



Sentinel Patients: Value of an Information System Collecting Patient’s Own Report on His Healthcare Management



Atsou K, Chouaid C, Hejblum G. Variability of the chronic obstructive pulmonary disease key epidemiological data in Europe: systematic review.

BMC Med

2011;9:7.



Hejblum G, Ioos V, Vibert JF, Boelle PY, Chalumeau-Lemoine L, Chouaid C, Valleron AJ, Guidet B. A web-based Delphi study on the indications of chest radiographs for patients in ICUs.

Chest

2008;133:1107-12.


 


Randomized trials

- The HYPAGE study



Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription (HYPAGE)

- The SENTIPAT Study



Feldman SF, Lapidus N, Cosnes J, Tiret E, Fonquernie L; Cabane J, Chazouilleres O, Surgers L, Beaussier M, Valleron AJ, Carrat F, Hejblum G. Comparing inpatient satisfaction collected via a web-based questionnaire self-completion and through a telephone interview: an ancillary study of the SENTIPAT randomized controlled trial.

J Med Internet Res

(in the press).



Couturier B, Carrat F, Hejblum G. Comparing Patients’ opinions on the hospital discharge process collected with a self-reported questionnaire completed via the Internet or through a telephone survey: an ancillary study of the SENTIPAT randomized controlled trial.

J Med Internet Res

2015;17:e158.



Sentinel Patients: Value of an Information System Collecting Patient's Own Report on His Healthcare Management

- The ICE-CUB I and ICE-CUBII studies:



Boumendil A, Woimant M, Quenot JP, Rooryck FX, Makhlouf F, Yordanov Y, Delerme S, Takun K, Ray P, Kouka MC, Poly C, Garrouste-Orgeas M, Thomas C, Simon T, Azerad S, Leblanc G, Pateron D, Guidet B; ICE-CUB 2 study network. Designing and conducting a cluster-randomized trial of ICU admission for the elderly patients: the ICE-CUB 2 study.

Ann Intensive Care

2016;6(1):63


Impact on Mid-term Mortality of Guidelines for ICU Admission of Elderly Patients Arriving in Emergency Departments (ICECUBII)



Boumendil A, Angus DC, Guitonneau AL, Menn AM, Ginsburg C, Takun K, Davido A, Masmoudi R, Doumenc B, Pateron D, Garrouste-Orgeas M, Somme D, Simon T, Aegerter P, Guidet B; ICE-CUB study group. Variability of intensive care admission decisions for the very elderly.

PLoS One

2012;7(4):e34387.



Boumendil A, Latouche A, Guidet B. On the benefit of intensive care for very old patients.

Arch Intern Med

2011;171:1116-7.

- The RARE study:



Hejblum G, Chalumeau-Lemoine L, Ioos V, Boelle PY, Salomon L, Simon T, Vibert JF, Guidet B. Comparison of routine and on-demand prescription of chest radiographs in mechanically ventilated adults: a multicentre, cluster-randomised, two-period crossover study.

Lancet

2009;374:1687-93.

 


Documenting the current situation



Couturier B, Carrat F, Hejblum G. A Systematic Review on the Effect of the Organization of Hospital Discharge on Patient Health Outcomes.

BMJ Open

2016;6(12):e012287.



Jolivot PA, Pichereau C, Hindlet P, Hejblum G, Bigé N, Maury E, Guidet B, Fernandez C. An observational study of adult admissions to a medical ICU due to adverse drug events.

Ann Intensive Care

2016;6(1):9.


Bigé N, Hejblum G, Baudel J, Carron A, Chevalier S, Pichereau C, Maury E, Guidet B. Homeless patients in the Intensive Care Unit: an observational propensity-matched cohort study.

Crit Care Med

2015;2015;43:1246-54.



Galbois A, Aegerter P, Martel-Samb P, Housset C, Thabut D, Offenstadt G, Ait-Oufella H, Maury E, Guidet B. Improved prognosis of septic shock in patients with cirrhosis: a multicenter study.

Crit Care Med

2014;42:1666-75.



Jolivot PA, Hindlet P, Pichereau C, Fernandez C, Maury E, Guidet B, Hejblum G. A systematic review of adult admissions to ICUs related to adverse drug events.

Crit Care

2014;18:643.



Atsou K, Chouaid C, Hejblum G. Variability of the chronic obstructive pulmonary disease key epidemiological data in Europe: systematic review.

BMC Med

2011;9:7.



Nguyen YL, Milbrandt EB, Weissfeld LA, Kahn JM, Chiche JD, Aegerter P, Clermont G, Kellum JA, Guidet B, Angus DC. Intensive care unit renal support therapy volume is not associated with patient outcome.

Crit Care Med

2011;39:2470-7.



Valentin A, Capuzzo M, Guidet B, Moreno R, Metnitz B, Bauer P, Metnitz P. Errors in administration of parenteral drugs in intensive care units: multinational prospective study.

BMJ

2009;338:b814.



Valin N, Hejblum G, Borget I, Mallet HP, Antoun F, Che D, Chouaid C. Management and treatment outcomes of tuberculous patients, eastern Paris, France, 2004.

Int J Tuberc Lung Dis

2009;13:881-7.


 


Patient satisfaction and patient opinion



Feldman SF, Lapidus N, Cosnes J, Tiret E, Fonquernie L; Cabane J, Chazouilleres O, Surgers L, Beaussier M, Valleron AJ, Carrat F, Hejblum G. Comparing inpatient satisfaction collected via a web-based questionnaire self-completion and through a telephone interview: an ancillary study of the SENTIPAT randomized controlled trial.

J Med Internet Res

(in the press).



Macquart de Terline D, Hejblum G, Fernandez C, Cohen A, Antignac M. Discrepancies Between Patients’ Preferences and Educational Programs on Oral Anticoagulant Therapy: A Survey in Community Pharmacies and Hospital Consultations.

PLoS One

2016;11(1):e0146927.



Couturier B, Carrat F, Hejblum G; SENTIPAT Study Group. Comparing patients’ opinions on the hospital discharge process collected with a self-reported questionnaire completed via the Internet or through a telephone survey: an ancillary study of the SENTIPAT randomized controlled trial.

J Med Internet Res

2015;17:e158.



Sentinel Patients: Value of an Information System Collecting Patient’s Own Report on His Healthcare Management


 


Elderly patients



Impact on Mid-term Mortality of Guidelines for ICU Admission of Elderly Patients Arriving in Emergency Departments (ICECUBII)



Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription (HYPAGE)



Guidet B, Hodgson E, Feldman C, Paruk F, Lipman J, Koh Y, Vincent JL, Azoulay E, Sprung CL. The Durban World Congress Ethics Round Table Conference Report: II. Withholding or withdrawing of treatment in elderly patients admitted to the intensive care unit.

J Crit Care

2014;29:896-901.



Boumendil A, Angus DC, Guitonneau AL, Menn AM, Ginsburg C, Takun K, Davido A, Masmoudi R, Doumenc B, Pateron D, Garrouste-Orgeas M, Somme D, Simon T, Aegerter P, Guidet B; ICE-CUB study group. Variability of intensive care admission decisions for the very elderly.

PLoS One

2012;7(4):e34387. Epub 2012 Apr 11.



Boumendil A, Latouche A, Guidet B. On the benefit of intensive care for very old patients.

Arch Intern Med

2011;171:1116-7.



Nguyen YL, Angus DC, Boumendil A, Guidet B. The challenge of admitting the very elderly to intensive care.

Ann Intensive Care

2011;1(1):29.


 


Adverse events



Hernandez F, Majoul E, Montes-Palacios C, Antignac M, Cherrier B, Doursounian L, Feron JM, Robert C, Hejblum G, Fernandez C, Hindlet P. An Observational Study of the Impact of a Computerized Physician Order Entry System on the Rate of Medication Errors in an Orthopaedic Surgery Unit.

PLoS One

2015;10:e0134101.



Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription (HYPAGE)



Sentinel Patients: Value of an Information System Collecting Patient’s Own Report on His Healthcare Management



Jolivot PA, Hindlet P, Pichereau C, Fernandez C, Maury E, Guidet B, Hejblum G. A systematic review of adult admissions to ICUs related to adverse drug events.

Crit Care

2014;18:643.





Membres de l'équipe

Nom Contact Statut / Fonction
Salomé ATTIA salome.attia at iplesp.upmc.fr Etudiant-e / Stagiaire de Master
Elsa BOURCIER elsa.bourcier at iplesp.upmc.fr Doctorant-e
Simon BOURCIER simon.bourcier at iplesp.upmc.fr Doctorant-e
Bérengère COUTURIER-BARBARAY berengere.couturier at aphp.fr Doctorant-e
Christine FERNANDEZ christine.fernandez at sat.aphp.fr PU-PH
Bertrand GUIDET bertrand.guidet at sat.aphp.fr PU-PH
Gilles HEJBLUM gilles.hejblum at upmc.fr Chargé de Recherche
Patrick HINDLET patrick.hindlet at sat.aphp.fr MCU-PH
Pierre-Alain JOLIVOT Doctorant-e
Eric MAURY eric.maury at sat.aphp.fr PU-PH
Yen-Lân NGUYEN yenlanc.nguyen at upmc.fr Praticien attaché